TRIMEFI ORAL

Composition:

Each mL of oral suspension contains:
Sodium sulfadiazine 400 mg
(Equivalent in Sulfadiazine base 367,7 mg)
Trimethoprim 80 mg
Excipients q.s. 1mL

Indications:

In dogs and cats for the treatment of infectious diseases caused by Escherichia coli, Proteus sp., Streptococcus sp., Staphylococcus sp., Nocardia sp., Isospora sp. and Eimeria sp.

In poultry (broilers and replacement birds), cattle, pigs and horses for the treatment of infectious diseases caused by: Haemophilus sp., Pasteurella sp., Escherichia coli, Proteus sp., Streptococcus sp.

Species for which it is recommended:

Bovines, equines, porcines, dogs, cats and poultry (broilers and replacement birds).

Route of administration:

Orally.

In birds and pigs: orally in drinking water.

Dosage:

Bovines: administer 30 mg of trimethoprim sulfadiazine per kg of body weight, in practice 3 mL of TRIMEFI oral suspension per 50 kg of weight. Treatment every 24 hours for a period of 5 days.

Equines:administer 30 mg of trimethoprim sulfadiazine per kg of body weight, in practice 3 mL of TRIMEFI oral suspension per 50 kg of weight, every 24 hours for 5 days.

Porcines: administer 48 mg of trimethoprim sulfadiazine per kg of body weight, in practice 2 mL of TRIMEFI oral suspension per 16 kg of weight. To administer in drinking water, dilute 20 mL of TRIMEFI oral suspension for every 15 liters of water per day, treatment for 3 to 5 days.

Dogs and cats: administer 30 mg of trimethoprim sulfadiazine per kg of body weight, in practice 1 mL of TRIMEFI oral suspension per 16 kg of weight. Treatment every 24 hours for 5 days.

To treat Nocardia sp. the dose is 60 mg of trimethoprim sulfadiazine per kg of body weight. In practice, administer 2 mL of TRIMEFI oral suspension for every 16 kg of weight.

Poultry: sdminister 25 mg of trimethoprim sulfadiazine for every kg of body weight, in practice dissolve 1 mL of TRIMEFI oral suspension in drinking water for every 2-3 liters of water according to age. Treatment for 3 to 5 days.

Withdrawal time:

Treated birds should not be slaughtered for human consumption until 10 days after the end of treatment. Treated cattle should not be slaughtered for human consumption until 10 days after the end of treatment.
The milk produced during the treatment and 72 hours after the end of the treatment should not be given to human consumption.
Treated pigs should not be slaughtered for human consumption until 15 days after the end of treatment.
Do not administer to birds whose eggs are intended for human consumption.
Do not administer to horses intended for human consumption.

Cautions:

Shake very well before use.
Do not use in pregnant females.
Do not use in patients with liver damage, blood dyscrasias, urolithiasis or hypersensitivity to sulfonamides.
Co-administration of antacids may decrease their bioavailability.
Doberman Pinscher dogs are more susceptible to the side effects that the medication can cause, such as polyarthritis, erythema, fever and anemia.
It can cause dry conjunctivitis in small species.
In treatments of more than 10 days, polyarthritis and fever may develop, which subside when the therapy is discontinued.
Pigs and birds: if a decrease in the water intake of sick animals is observed, reconsider the route of administration of the treatment.
For livestock farms, it is recommended to carry out sensitivity tests by culture/antibiogram prior to administration.
Coadministration with alpha-2 adrenergic agents or anesthetics is not recommended.
Keep at a temperature below 30 °C.

Presentations: HDPE bottle for 15, 30, 50, 60, 100, 250, 500 and 1000 mL.